Post-treatment control or treated controllers? Viral remission in treated and untreated primary HIV infection
| Autor: | Martin, G, Gossez, M, Williams, J, Stöhr, W, Meyerowitz, J, Leitman, E, Goulder, P, Porter, K, Fidler, S, Frater, J, Investigators, SPARTAC Trial |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Zdroj: | AIDS. 31(4) |
| ISSN: | 0269-9370 1473-5571 |
| Popis: | OBJECTIVE(S): An HIV cure will impose aviraemia that is sustained following the withdrawal of antiretroviral therapy (ART). Understanding the efficacy of novel interventions aimed at curing HIV requires characterization of both natural viral control and the effect of ART on viral control after treatment interruption. DESIGN: Analysis of transient viral control in recent seroconverters in the Short Pulse AntiRetroviral Therapy at Acute Seroconversion trial. METHODS: We compared untreated and treated HIV seroconverters (n = 292) and identified periods of control (plasma HIV RNA RESULTS: At baseline, future controllers had lower HIV DNA, lower plasma HIV RNA, higher CD4 : CD8 ratios (all P CONCLUSION: Consideration of spontaneous remission in untreated individuals will be critical to avoid overestimating the effect size of new interventions used in HIV cure studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|