Molecular definition of the identity and activation of natural killer cells
| Autor: | Bezman, Natalie A, Kim, Charles C, Sun, Joseph C, Min-Oo, Gundula, Hendricks, Deborah W, Kamimura, Yosuke, Best, J Adam, Goldrath, Ananda W, Lanier, Lewis L, Immunological Genome Project Consortium |
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| Rok vydání: | 2012 |
| Předmět: |
Cultured
1.1 Normal biological development and functioning T-Lymphocytes Cells Gene Expression Profiling Human Genome Immunology Cell Differentiation Immunological Genome Project Consortium Lymphocyte Activation Mice Genetic Underpinning research Genetics Natural Killer Cells Animals Humans Transcription Signal Transduction |
| Zdroj: | Nature immunology, vol 13, iss 10 |
| Popis: | Using whole-genome microarray data sets of the Immunological Genome Project, we demonstrate a closer transcriptional relationship between NK cells and T cells than between any other leukocytes, distinguished by their shared expression of genes encoding molecules with similar signaling functions. Whereas resting NK cells are known to share expression of a few genes with cytotoxic CD8(+) T cells, our transcriptome-wide analysis demonstrates that the commonalities extend to hundreds of genes, many encoding molecules with unknown functions. Resting NK cells demonstrate a 'preprimed' state compared with naive T cells, which allows NK cells to respond more rapidly to viral infection. Collectively, our data provide a global context for known and previously unknown molecular aspects of NK cell identity and function by delineating the genome-wide repertoire of gene expression of NK cells in various states. |
| Databáze: | OpenAIRE |
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