| Autor: |
Hullegie, SJ, Arends, JE, Rijnders, BJ, Irving, WL, Salmon, D, Prins, M, Wensing, AM, Klenerman, P, Leblebicioglu, H, Boesecke, C, Rockstroh, JK, Hoepelman, AI |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| DOI: |
10.1016/j.cmi.2015.03.026 |
| Popis: |
Acute hepatitis C virus (AHCV) infections are frequently seen worldwide in certain risk groups with an annual incidence rate varying between 0.08% and 66%. Although this incidence is substantial, a delayed diagnosis during chronic infection is most often made in the absence of clinical symptoms in the acute phase of the infection. Current used methods to diagnose AHCV are IgG antibody seroconversion and repeated HCV RNA measurements though no definite diagnostic test is currently available. Progress in the field of adaptive and innate immune responses has aided to both advancements in the field of HCV vaccine development and a more basic understanding of viral persistence. The rapid changes in the treatment of chronic HCV will affect therapeutic regimens in AHCV in the coming years leading to shorter treatment courses and pegylated interferon-free modalities. This review gives an overview of the current knowledge and uncertainties together with some future perspectives on acute HCV epidemiology, virology, immunology and treatment. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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