Click glycoconjugation of per-azido- and alkynyl-functionalized beta-peptides built from aspartic acid
| Autor: | Barra, Marielle, Roy, Olivier, Traïkia, Mounir, Taillefumier, Claude |
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| Přispěvatelé: | Synthèse et étude de systèmes à intêret biologique (SEESIB), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Bonnefoy, Stéphanie |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Zdroj: | Organic & Biomolecular Chemistry Organic & Biomolecular Chemistry, 2010, 8, pp.2941-2955 Organic and Biomolecular Chemistry Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2010, pp.2941-2955 |
| ISSN: | 1477-0520 1477-0539 |
| Popis: | International audience; Azide- and alkynyl-containing homo-beta3-peptides, of up to six residues in length, were synthesised in solution from aspartic acid. Their subsequent conjugation with monosaccharides bearing an azide or a terminal alkyne function was efficiently achieved by copper-mediated cycloadditions leading to two novel families of small glycoclusters. These compounds represent ideal tools to explore carbohydrate-mediated multivalent interactions |
| Databáze: | OpenAIRE |
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