Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance
| Autor: | Chong Yew Tan, Samuel Virtue, Steven Murfitt, Lee D. Robert, Yi Hui Phua, Martin Dale, Julian L. Griffin, Francisco Tinahones, Philipp E. Scherer, Antonio Vidal-Puig |
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| Přispěvatelé: | [Yew Tan,C, Virtue,S, Dale,M, Vidal-Puig,A] University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, MDU MRC. Addenbrooke’s Hospital, Cambridge, UK. [Murfitt,S, Robert,LD, Phua,YH, Griffin,JL] University of Cambridge Department of Biochemistry, Cambridge, UK. [Tinahones,FJ] UGC Endocrinologia y Nutrición (IBIMA), Hospital Virgen de la Victoria. CIBER of Physiopathology, Obesity and Nutrition (CIBEROBN) Málaga, Spain. [Scherer,P] Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA. [Vidal-Puig,A] Wellcome Trust Sanger Institute, Hinxton, Uk. [Robert,LD, Griffin,JL] Medical Research Council – Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, Uk., BB/H002731/1, Biotechnology and Biological Sciences Research Council, United Kingdom, BB/H013539/1, Biotechnology and Biological Sciences Research Council, United Kingdom, MC_G0802535, Medical Research Council, United Kingdom, MC_PC_13030, Medical Research Council, United Kingdom, MC_UP_A090_1006, Medical Research Council, United Kingdom, MC_UU_12012/2, Medical Research Council, United Kingdom, RG/12/13/29853, British Heart Foundation, United Kingdom, Griffin, Julian [0000-0003-1336-7744], Vidal-Puig, Antonio [0000-0003-4220-9577], Apollo - University of Cambridge Repository |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Tejido adiposo Adenosine Deaminase Fatty Acid Elongases Chemicals and Drugs::Hormones Hormone Substitutes and Hormone Antagonists::Hormones::Peptide Hormones::Adipokines::Adiponectin [Medical Subject Headings] Adipose Tissue White Obesidad Mice Obese Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Drug Resistance::Insulin Resistance [Medical Subject Headings] Grasa intra-abdominal Severity of Illness Index Gato Grasa subcutánea Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] Mice Acetyltransferases Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids Unsaturated::Fatty Acids Essential [Medical Subject Headings] Organisms::Eukaryota::Animals [Medical Subject Headings] Animals Obesity Anatomy::Tissues::Connective Tissue::Adipose Tissue::Adipose Tissue White::Abdominal Fat::Intra-Abdominal Fat [Medical Subject Headings] Triglycerides Chemicals and Drugs::Lipids::Glycerides::Triglycerides [Medical Subject Headings] Mice Knockout Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice [Medical Subject Headings] Fatty Acids food and beverages Anatomy::Tissues::Connective Tissue::Adipose Tissue [Medical Subject Headings] Humanos Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity [Medical Subject Headings] Chemicals and Drugs::Inorganic Chemicals::Elements::Carbon [Medical Subject Headings] Ácidos grasos monoinsaturados Adiposidad Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Body Composition::Body Fat Distribution::Adiposity [Medical Subject Headings] Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids Unsaturated::Fatty Acids Monounsaturated [Medical Subject Headings] Female lipids (amino acids peptides and proteins) Insulin Resistance Adiponectina Ácidos grasos esenciales |
| Popis: | Journal Article; The non-essential fatty acids, C18:1n9, C16:0, C16:1n7, C18:0 and C18:1n7 account for over 75% of fatty acids in white adipose (WAT) triacylglycerol (TAG). The relative composition of these fatty acids (FA) is influenced by the desaturases, SCD1-4 and the elongase, ELOVL6. In knock-out models, loss of SCD1 or ELOVL6 results in reduced Δ9 desaturated and reduced 18-carbon non-essential FA respectively. Both Elovl6 KO and SCD1 KO mice exhibit improved insulin sensitivity. Here we describe the relationship between WAT TAG composition in obese mouse models and obese humans stratified for insulin resistance. In mouse models with increasing obesity and insulin resistance, there was an increase in scWAT Δ9 desaturated FAs (SCD ratio) and FAs with 18-carbons (Elovl6 ratio) in mice. Data from mouse models discordant for obesity and insulin resistance (AKT2 KO, Adiponectin aP2-transgenic), suggested that scWAT TAG Elovl6 ratio was associated with insulin sensitivity, whereas SCD1 ratio was associated with fat mass. In humans, a greater SCD1 and Elovl6 ratio was found in metabolically more harmful visceral adipose tissue when compared to subcutaneous adipose tissue. Yes |
| Databáze: | OpenAIRE |
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