MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients
| Autor: | Langers, AMJ, Verspaget, HW, Hawinkels, LJAC, Kubben, FJGM, van Duijn, W, van der Reijden, JJ, Hardwick, JCH, Hommes, DW, Sier, CFM |
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| Rok vydání: | 2012 |
| Předmět: |
Male
matrix metalloproteinase Oncology and Carcinogenesis SNP Enzyme-Linked Immunosorbent Assay carcinoma Polymerase Chain Reaction survival normal mucosa angiogenesis Humans 2.1 Biological and endogenous factors Prospective Studies Oncology & Carcinogenesis Polymorphism Aetiology Neoplasm Staging Retrospective Studies Aged Cancer Mucous Membrane Single Nucleotide Prognosis Colo-Rectal Cancer Survival Rate Restriction Fragment Length Matrix Metalloproteinase 9 Public Health and Health Services Matrix Metalloproteinase 2 Female ELISA Colorectal Neoplasms Digestive Diseases |
| Zdroj: | British journal of cancer, vol 106, iss 9 |
| Popis: | BackgroundUpregulation of the matrix metalloproteinases MMP-2 and MMP-9 in various cancers has been associated with worse survival of the patients.MethodsWe assessed MMP-2 and MMP-9 levels in normal colorectal mucosa from colorectal cancer patients in relation to the course of the disease.ResultsA high protein expression of MMP-2 as well as MMP-9 in normal mucosa was found to be correlated with worse 5-year survival. The combination of both parameters was an even stronger prognostic factor. These protein levels were found not to be related to the corresponding single nucleotide polymorphisms of MMP-2 (-1306C>T) and MMP-9 (-1562C>T). Multivariate analyses indicated that the MMP-2 and MMP-9 levels in normal mucosa are prognostic for survival, independent of TNM classification.ConclusionMMP-2 and MMP-9 levels in normal mucosa are indicative of the course of disease in colorectal cancer patients. |
| Databáze: | OpenAIRE |
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