Peroxins Pex30 and Pex29 Dynamically Associate with Reticulons to Regulate Peroxisome Biogenesis from the Endoplasmic Reticulum
| Autor: | Mast, FD, Jamakhandi, A, Saleem, RA, Dilworth, DJ, Rogers, RS, Rachubinski, RA, Aitchison, JD |
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| Rok vydání: | 2016 |
| Předmět: |
Biochemistry & Molecular Biology
Saccharomyces cerevisiae Proteins peroxin reticulon 1.1 Normal biological development and functioning Membrane Transport Proteins Membrane Proteins peroxisomes Saccharomyces cerevisiae yeast Biological Sciences Endoplasmic Reticulum Medical and Health Sciences subcellular fractionation subcellular organelle Chemical Sciences microscopy peroxisome |
| Zdroj: | The Journal of biological chemistry, vol 291, iss 30 Mast, FD; Jamakhandi, A; Saleem, RA; Dilworth, DJ; Rogers, RS; Rachubinski, RA; et al.(2016). Peroxins Pex30 and Pex29 dynamically associate with reticulons to regulate peroxisome biogenesis from the endoplasmic reticulum. Journal of Biological Chemistry, 291(30), 15408-15427. doi: 10.1074/jbc.M116.728154. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/5tm9h5kx |
| DOI: | 10.1074/jbc.M116.728154. |
| Popis: | © 2016 by The American Society for Biochemistry and Molecular Biology, Inc. Peroxisome proliferation occurs by at least two routes, division of existing peroxisomes and de novo biogenesis from the endoplasmic reticulum (ER). The proteins and molecular mechanisms governing peroxisome emergence from the ER are poorly characterized. In this study, we report that two integral membrane peroxins (proteins required for peroxisome biogenesis) in Saccharomyces cerevisiae, Pex29 and Pex30, reside in distinct regions of the ER and associate with Rtn1 and Yop1, reticulon family members that contribute to ER morphology, to govern peroxisome emergence from the ER. In vivo and in vitro analyses reveal that peroxisome proliferation is therefore not restricted to the peroxisome but begins at the level of the ER. |
| Databáze: | OpenAIRE |
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