Molecular interplay betweeen cáncer cell fatty acid metabolism and oncogenic signaling as resource for novel treatment strategies against ovarian cancer

Autor:	Wagner, Renate, Veigel, Daniel, Prostling, K., Stübiger, Gerald, Grusch, Michael, Weghuber, J., Singer, Christian F., Karlic, H., Colomer, Ramón, López-Rodríguez, María Luz, Benhamú, Bellinda, Hegardt, Fausto, Serra i Cucurull, Dolors, García Gómez, Jordi, Valent, Peter, Grunt, Thomas
Přispěvatelé:	Universitat de Barcelona
Předmět:	Fallopian tubes Trompes de Fal·lopi Ovarian cancer Antineoplastic agents Càncer d'ovari Àcids grassos Fatty acids Medicaments antineoplàstics
Zdroj:	Recercat. Dipósit de la Recerca de Catalunya instname Dipòsit Digital de la UB Universidad de Barcelona
Popis:	The metabolic oncogene fatty acid synthase (FASN) is overexpressed in 80% of ovarian cancers (OC) and indicates poor prognosis. Exposure of OC to inhibitors of FASN elicits a complex stress response that interferes with receptor-PI3K-mTORC1 signaling (briefly designated 'PI3K pathway'). Here we demonstrate that FASN inhibitors capitalize on multiple mechanisms to interfere with the PI3K pathway, and that silencing this cascade is crucial for the anticancer action of the drugs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::d827abe351ffd25b788e17ac49c421ea http://hdl.handle.net/2445/97402 Zobrazit plný text záznamu