Prognostic factors of a lower CD4/CD8 ratio in long term viral suppression HIV infected children

Autor: Guillen, S, Prieto, L, de Ory, SJ, Gonzalez-Tome, MI, Rojo, P, Navarro, ML, Mellado, MJ, Escosa, L, Sainz, T, Francisco, L, Munoz-Fernandez, MA, Ramos, JT, Hortelano, MG, Blazquez, D, Epalza, C, Saavedra, J, Santos, M, Munoz, MA, Santiago, B, Carrasco, I, Roa, MA, Beceiro, J, Penin, M, Martinez, J, Badillo, K, Apilanez, M, Pocheville, I, Garrote, E, Colino, E, Sirvent, JG, Garzon, M, Roman, V, Munoz, MJ, Angulo, R, Neth, O, Falcon, L, Terol, P, Santos, JL, Moreno, D, Lendinez, F, Peromingo, E, Montero, M, Grande, A, Romero, FJ, Perez, C, Martinez, M, Lillo, M, Losada, B, Herranz, M, Bustillo, M, Guerrero, C, Collado, P, Couceiro, JA, Vila, L, Calvino, C, Piqueras, AI, Breton, R, Oltra, M, Lopez, E, Segarra, I, Gavilan, C, Montesinos, E, Dapena, M, Alvarez, C, Jimenez, B, Andres, AG, Marugan, V, Ochoa, C, Alfayate, S, Menasalvas, AI, del Prado, YR, Soler-Palacin, P, Frick, MA, Mur, A, Lopez, N, Mendez, M, Mayol, L, Vallmanya, T, Calavia, O, Garcia, L, Pineda, V, Rius, N, Duenas, J, Fortuny, C, Noguera-Julian, A
Jazyk: angličtina
Rok vydání: 2021
Zdroj: Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
Zaguán. Repositorio Digital de la Universidad de Zaragoza
Servizo Galego de Saúde (SERGAS)
PLoS ONE
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
ISSN: 1932-6203
Popis: Background Combination antiretroviral therapy (cART) is associated with marked immune reconstitution. Although a long term viral suppression is achievable, not all children however, attain complete immunological recovery due to persistent immune activation. We use CD4/CD8 ratio like a marker of immune reconstitution. Methods Perinatal HIV-infected children who underwent a first-line cART, achieved viral suppression in the first year and maintained it for more than 5 years, with no viral rebound were included. Logistic models were applied to estimate the prognostic factors, clinical characteristics at cART start, of a lower CD4/CD8 ratio at the last visit. Results 146 HIV-infected children were included: 77% Caucasian, 45% male and 28% CDC C. Median age at cART initiation was 2.3 years (IQR: 0.5-6.2). 42 (30%) children received mono-dual therapy previously to cART. Time of undetectable viral load was 9.5 years (IQR: 7.8, 12.5). 33% of the children not achieved CD4/CD8 ratio >1. Univariate analysis showed an association between CD4/CD8 1 was not achieved in 33% of the children. Lower CD4 nadir and previous exposure to suboptimal therapy, before initiating cART, are factors showing independently association with a worse immune recovery (CD4/CD8 < 1).
Databáze: OpenAIRE
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