Synthesis and Antimicrobial Activity of Some Taurinamide Derivatives
| Autor: | Akgul, Ozlem, Ozturk, Ismail, Aygul, Abdurrahman, Ermertcan, Safak |
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| Přispěvatelé: | Ege Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Popis: | WOS: 000411289700021 In this study, a series of taurinamide derivatives were synthesized and screened for their antimicrobial activity. The structures of the newly synthesized compounds 11-15 were evaluated by H-1 NMR, IR, MS-APCI and elemental analysis. Compounds (1-15) were tested against standard strains of Gram(+), Gram(-) bacteria and fungi by using disc diffusion and broth microdilution methods. Although disc diffusion method did not show any comparable results due to the solubility properties of the compounds; microdilution method results indicated that title compounds showed from poor to good activity against only Enterococcus faecalis. It can be concluded that phtalimido moiety, secondary aryl sulphonamide group and electron-donating group substitution on phenyl ring are essential for the antibacterial activity. Among the tested compounds, para substituted methyl and methoxy derivatives of N-phenyl-2-phthalimidotaurinamide (4, 7), displayed equipotent activity compared to standard drug gentamicin. Ege UniversityEge University [12/Ecz/24] This work was supported by research grant from Ege University (Project Number: 12/Ecz/24). The authors gratefully acknowledge Pharmaceutical Sciences Research Center (FABAL) of the Faculty of Pharmacy, Ege University for providing spectral analysis. |
| Databáze: | OpenAIRE |
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