Polycaprolactone-b-poly(ethylene oxide) biocompatible micelles as dynamic light scattering drug delivery nanocarriers: Dynamic light scattering and fluorescence experiments

Autor: Giacomelli, Cristiano, Lafitte, G., Borsali, Redouane
Přispěvatelé: Laboratoire de Chimie des polymères organiques (LCPO), Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Université Sciences et Technologies - Bordeaux 1-Institut de Chimie du CNRS (INC), Team 3 LCPO : Polymer Self-Assembly & Life Sciences, Laboratoire de Chimie des Polymères Organiques (LCPO), Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC), RICHARD, Dominique
Jazyk: angličtina
Rok vydání: 2005
Předmět:
Zdroj: Macromolecular Symposia
Macromolecular Symposia, Wiley-VCH Verlag, 2005, 229, pp.107-117
ISSN: 1022-1360
1521-3900
Popis: International audience; Dynamic light scattering (DLS) and fluorescence experiments were carried out to study PCL44-b-PEO114 biocompatible micelles used as nanocarriers in drug delivery. Micelles prepared by a simple procedure (THF removal under nitrogen flow) exhibited a narrow size distribution with an average diameter of 100nm. For micelles containing a hydrophobic model compound (pyrene) within the PCL core, a smaller average micellar size of 80 nm was observed, with a simultaneous broadening in the size distribution profile. in parallel to DLS results, fluorescence experiments showed evidence of pyrene encapsulation, and that the onset of the micellization process occurs at approximately 10/90 (v/v) THF/water mixtures in the case of PCL44-b-PEO114 polymer.
Databáze: OpenAIRE
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