Hallmarks of frailty and osteosarcopenia in prematurely aged PolgA(D257A/D257A) mice

Autor: Scheuren, Ariane C., D'Hulst, Gommaar, Kuhn, Gisela A., Masschelein, Evi, Wehrle, Esther, De Bock, Katrien, Müller, Ralph
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 4, Pp 1121-1140 (2020)
ISSN: 2190-5991
2190-6009
Popis: Background Frailty is a geriatric syndrome characterized by increased susceptibility to adverse health outcomes. One major determinant thereof is the gradual weakening of the musculoskeletal system and the associated osteosarcopenia. To improve our understanding of the underlying pathophysiology and, more importantly, to test potential interventions aimed at counteracting frailty, suitable animal models are needed. Methods To evaluate the relevance of prematurely aged PolgA(D257A/D257A) mice as a model for frailty and osteosarcopenia, we quantified the clinical mouse frailty index in PolgA(D257A/D257A) and wild‐type littermates (PolgA(+/+), WT) with age and concertedly assessed the quantity and quality of bone and muscle tissue. Lastly, the anabolic responsiveness of skeletal muscle, muscle progenitors, and bone was assessed. Results PolgA(D257A/D257A) accumulated health deficits at a higher rate compared with WT, resulting in a higher frailty index at 40 and 46 weeks of age (+166%, +278%, P
Databáze: OpenAIRE
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