Low-dose myocardial blood flow imaging using 82Rb-PET (RUBILOW 2.0)
| Autor: | Camilla Molich Hoff, Lars Poulsen Tolbod, Hans Harms, Kirsten Bouchelouche, Jørgen Frøkiær, Jens Sørensen |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Zdroj: | Hoff, C M, Tolbod, L P, Harms, H, Bouchelouche, K, Frøkiær, J & Sørensen, J 2017, ' Low-dose myocardial blood flow imaging using 82Rb-PET (RUBILOW 2.0) ', European Journal of Nuclear Medicine and Molecular Imaging, vol. 44, no. Suppl 2 . Aarhus University |
| Popis: | Aim: Relative and absolute measures of myocardial blood flow (MBF) can be derived from a 82Rb PET/CT scan using list mode data to extract static, gated and dynamic PET series. High doses of 82Rb are used to maximize image quality in especially static images. High doses require large eluate volumes, may degrade scanner dead time performance at first pass and decreases generator lifetime. Lower doses will expand the availability of 82Rb PET/CT and lower doses to personnel and patients. The aim of the current study was to examine MBF with a low dose (LD) 82Rb protocol compared to the institution’s standard (STD) protocol. Methods: Twenty-one patients referred to 82Rb PET were included in the study. Patients were examined during rest and stress with repeated LD (740 MBq) and STD dose (1110 MBq) Rb-PET during the same imaging session. Regional and global rest and stress MBF values, total perfusion deficit (TPD), ejection fraction (EF) and %-perfusion using the 17-segment model were calculated using commercially available software QPET (Cedars Sinai). Results: Five patients had to be excluded due to motion during STD (n=2) and LD (n=3). For the remaining patients, there was excellent correlation between STD and LD global MBF (STD=0.91xLD+ 0.08, R²=0.95, p |
| Databáze: | OpenAIRE |
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