Des niveaux élevés de miR-7-5p potentialisent le cytokilling induit par le crizotinib et le flux autophagique en ciblant RAF1 dans les cellules de lymphome positives NPM-ALK
| Autor: | Sorrentino, Domenico, Frentzel, Julie, Mitou, Géraldine, Blasco, Rafael, Torossian, Avédis, Hoareau-Aveilla, Coralie, Pighi, Chiara, Farcé, Manon, MEGGETTO, FABIENNE, Manenti, Stéphane, Espinos, Estelle, Chiarle, Roberto, Giuriato, Sylvie |
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| Přispěvatelé: | Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Cancers Cancers, MDPI, 2020, 12 (10), pp.2951. ⟨10.3390/cancers12102951⟩ |
| ISSN: | 2072-6694 |
| Popis: | International audience; Anaplastic lymphoma kinase positive anaplastic large cell lymphomas are a pediatric disease, which still needs treatment improvement. Crizotinib was the first ALK-targeted inhibitor used in clinics, but relapses are now known to occur. Current research efforts indicate that combined therapies could represent a superior strategy to eradicate malignant cells and prevent tumor recurrence. Autophagy is a self-digestion cellular process, known to be induced upon diverse cancer therapies. Our present work demonstrates that the potentiation of the crizotinib-induced autophagy flux, through the serine/threonine kinase RAF1 downregulation, drives ALK+ ALCL cells to death. These results should encourage further investigations on the therapeutic modulation of autophagy in this particular cancer settings and other ALK-related malignancies. |
| Databáze: | OpenAIRE |
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