Intrinsic pKa values of 3'-N-α-L-aminoacyl-3'-aminodeoxyadenosines determined by pH dependent 1H NMR in H20

Autor:	Krishnakumar K., S., Michel B., Y., Nguyen-Trung N., Q., Fenet, B., Strazewski, P.
Přispěvatelé:	Depierre, Frédérique, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Jazyk:	angličtina
Rok vydání:	2011
Předmět:	[CHIM.ORGA]Chemical Sciences/Organic chemistry [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM] [CHIM.ORGA] Chemical Sciences/Organic chemistry [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM]
Zdroj:	Chemical Communications Chemical Communications, Royal Society of Chemistry, 2011, 47 (11), pp.3290-3292
ISSN:	1359-7345 1364-548X
Popis:	International audience; 3'-(α-L-Aminoacylamido)deoxyadenosines are ribosomal A-site binders and mimic the nascent peptide accepting 3'-terminus of aminoacyl transfer RNA. Their α-amino groups exhibit intrinsic basicities in bulk water that differ by up to 1.8 pK(a) units. Only the neutral form of these nucleophiles can be active during ribosomal peptidyl transfer catalysis.
Databáze:	OpenAIRE
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