Unique QM/MM Potential Energy Surface Exploration Using Microiterations

Autor: Melaccio, F, Olivucci, Massimo, Lindh, R, Ferre, N.
Přispěvatelé: Università degli Studi di Siena = University of Siena (UNISI), Dipartimento di Chimica, Chemistry Department, Bowling Green State University (BGSU), Department of Chemistry-Angstrom, the Theoretical Chemistry Programme, Uppsala University, Institut de Chimie Radicalaire (ICR), Aix Marseille Université (AMU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Zdroj: International Journal of Quantum Chemistry
International Journal of Quantum Chemistry, Wiley, 2011, 111 (13), pp.3339--3346. ⟨10.1002/qua.23067⟩
International Journal of Quantum Chemistry, 2011, 111 (13), pp.3339--3346. ⟨10.1002/qua.23067⟩
ISSN: 0020-7608
1097-461X
DOI: 10.1002/qua.23067⟩
Popis: WOS:000295110300016; International audience; The determination and the characterization of important points of a potential energy surface can be carried out routinely using any molecular modelling software based on either a quantum mechanical (QM) or a classical (molecular mechanics, MM) description of the particle interactions. However the coupling of the QM and MM descriptions (QM/MM) gives rise to severe efficiency limitations during a geometry optimization of the whole system, especially when both subsystems are coupled electrostatically. This work introduces two simple improvements, mainly developed in the framework of the electrostatic potential fitted method to ensure the uniqueness of the QM/MM potential energy surface. The first one aims to improve the approximate Hessian matrix used in the
Databáze: OpenAIRE
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