Triggering the resolution of inflammation with agonistic anti-ChemR23 antibody dampens inflammation-driven carcinogenesis and metastasis
| Autor: | Gauttier, Vanessa, Lavy, Margot, Trilleaud, Charlène, Biteau, Kévin, Neyton, Stéphanie, Girault, Isabelle, Belarif, Lyssia, Mary, Caroline, Teppaz, Géraldine, Thépénier, Virginie, Blanquart, Christophe, Barillé-Nion, Sophie, Poirier, Nicolas |
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| Přispěvatelé: | OSE Immunotherapeutics [Nantes], Immunogenic Cell Death and Mesothelioma Therapy (CRCINA-ÉQUIPE 4), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Stress Adaptation and Tumor Escape in Breast Cancer (CRCINA-ÉQUIPE 8), Bernardo, Elizabeth, Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | American Association for Cancer Researc 2021 American Association for Cancer Researc 2021, 2021, Virtual Meeting, United States |
| Popis: | International audience; Triggering the resolution of inflammation with agonistic anti-ChemR23 antibody dampens inflammation-driven carcinogenesis and metastasis Chronic inflammation is associated with abnormal non-phlogistic clearance (efferocytosis) of apoptotic cells by macrophages and a defect of the resolution of inflammation pathways. The resolution of inflammation is an active immunological process mediated by specialized pro-resolving mediator (SPM) which target specific resolutive G-protein coupled receptors expressed by different immune cells and participate at the return to tissue homeostasis after an injury. Defects in the clearance of (chemotherapy-induced) apoptotic tumor cell debris strengthens inflammation and has been associated with exacerbated tumor growth in several preclinical models. Proresolutive therapeutic approaches, such as using exogenous resolvin E1 (RvE1), the natural lipidic proresolutive ligand of GPCR ChemR23, have been shown to dampen tumor-associated inflammation and to reduce tumor growth. We found that ChemR23 is inducible on myeloid cells by inflammatory stimuli and mainly expressed by tumor associated macrophages in melanoma and lung cancers. We identified an agonist anti-ChemR23 mAb that accelerates the resolution of inflammation in acute inflammatory model in mice. Finally, we report that agonist anti-ChemR23 mAb limits chronic inflammation in the tumor microenvironment and inhibits metastasis development. |
| Databáze: | OpenAIRE |
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