Association of osteoprotegrin gene polymorphism with aortic stenosis

Autor:	Legčević, Zoran
Přispěvatelé:	Paić, Frane, Nikuševa Martić, Tamara, Šerman, Ljiljana
Jazyk:	chorvatština
Rok vydání:	2017
Předmět:	OPG gene Osteoprotegrin aortalna stenoza aortic valve stenosis genetic polimorphism
Popis:	Brojna istraživanja pokazala su prisutnost različitih genetskih promjena kod pacijenata sa aortalnom stenozom. U ovom radu ispitan je utjecaj rs3102735 (C/T tranzicija, supstitucija) SNP polimorfizma OPG gena na učestalost aortalne stenoze. Ispitivana populacija (n= 223) obuhvaća 92 pacijenta sa dijagnosticiranom aortalnom stenozom i 131 zdrava dobrovoljca koji čine kontrolnu skupinu ispitanika. Nije uočena statistički značajna razlika u distribuciji genotipova i alela rs3102735 (C/T tranzicija, supstitucija) SNP polimorfizma OPG gena između AVS pacijenata i kontrolne skupine ispitanika. Numerous research studies have shown association of genetic polimorphism with the prevalence of aortic valve stenosis. In this study we investigated the influence of rs3102735 (C/T transition, substitution) SNP polymorphism of OPG gene on incidence of aortic valve stenosis. Study population (n= 223) encompasses 92 aortic valve stenosis patients and 131 healthy control subjects. We did not detect any statistically significant difference in genotype or allele frequencies of rs3102735 between AVS patients and healthy control group.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::cfcd25b8cf71a53c09fa937b2798e8b7 https://urn.nsk.hr/urn:nbn:hr:105:424327 Zobrazit plný text záznamu