Chromatin Structure and Dynamics: Focus on Neuronal Differentiation and Pathological Implication
| Autor: | Nothof, Sophie A., Magdinier, Frédérique, Van-Gils, Julien |
|---|---|
| Přispěvatelé: | Marseille medical genetics - Centre de génétique médicale de Marseille (MMG), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Maladies Rares: Génétique et Métabolisme (Bordeaux) (U1211 INSERM/MRGM), Université de Bordeaux (UB)-Groupe hospitalier Pellegrin-Institut National de la Santé et de la Recherche Médicale (INSERM), Caugant, Julien |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
[SDV] Life Sciences [q-bio]
epigenetics chromatinopathies [SDV]Life Sciences [q-bio] [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry Molecular Biology/Genomics [q-bio.GN] chromatin histone modification methylation neuronal differentiation [SDV.BDD]Life Sciences [q-bio]/Development Biology acetylation |
| Zdroj: | Genes Genes, 2022, 13 (4), pp.639. ⟨10.3390/genes13040639⟩ Genes, MDPI, 2022, 13 (4), ⟨10.3390/genes13040639⟩ |
| ISSN: | 2073-4425 |
| Popis: | International audience; Chromatin structure is an essential regulator of gene expression. Its state of compaction contributes to the regulation of genetic programs, in particular during differentiation. Epigenetic processes, which include post-translational modifications of histones, DNA methylation and implication of non-coding RNA, are powerful regulators of gene expression. Neurogenesis and neuronal differentiation are spatio-temporally regulated events that allow the formation of the central nervous system components. Here, we review the chromatin structure and post-translational histone modifications associated with neuronal differentiation. Studying the impact of histone modifications on neuronal differentiation improves our understanding of the pathophysiological mechanisms of chromatinopathies and opens up new therapeutic avenues. In addition, we will discuss techniques for the analysis of histone modifications on a genome-wide scale and the pathologies associated with the dysregulation of the epigenetic machinery. |
| Databáze: | OpenAIRE |
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