Paradoxical Effect of Increased Diastolic Ca 2+ Release and Decreased Sinoatrial Node Activity in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia
| Autor: | Neco, Patricia, Torrente, Angelo, Mesirca, Pietro, Zorio, Esther, Liu, Nian, Priori, Silvia, Napolitano, Carlo, Richard, Sylvain, Benitah, Jean-Pierre, Mangoni, Matteo e., Gómez, Ana Maria |
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| Přispěvatelé: | Signalisation et physiopathologie cardiovasculaire (UMRS1180), Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Hospital La Fe [Valencia, Spain], Huazhong University of Science and Technology [Wuhan] (HUST), Molecular Cardiology, IRCCS Fondazione Salvatore Maugeri, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
MESH: Mutation
MESH: Mice Mutant Strains [SDV]Life Sciences [q-bio] MESH: Adrenergic beta-Agonists MESH: Calcium Signaling MESH: Isoproterenol MESH: Ryanodine Receptor Calcium Release Channel MESH: Mice Inbred C57BL MESH: Patch-Clamp Techniques MESH: Animals cardiovascular diseases MESH: Mice MESH: Action Potentials MESH: Aged MESH: In Vitro Techniques MESH: Middle Aged MESH: Humans MESH: Adult MESH: Male MESH: Exercise MESH: Calcium cardiovascular system MESH: Sarcoplasmic Reticulum MESH: Tachycardia Ventricular MESH: Disease Models Animal MESH: Sinoatrial Node MESH: Female |
| Zdroj: | Circulation Circulation, American Heart Association, 2012, 126 (4), pp.392-401. ⟨10.1161/CIRCULATIONAHA.111.075382⟩ |
| ISSN: | 0009-7322 1524-4539 |
| DOI: | 10.1161/CIRCULATIONAHA.111.075382⟩ |
| Popis: | International audience; Catecholaminergic polymorphic ventricular tachycardia is characterized by stress-triggered syncope and sudden death. Patients with catecholaminergic polymorphic ventricular tachycardia manifest sinoatrial node (SAN) dysfunction, the mechanisms of which remain unexplored. |
| Databáze: | OpenAIRE |
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