The macrophage activation marker sCD163 is associated with changes in NAFLD and metabolic profile during lifestyle intervention in obese children
| Autor: | Kazankov, K, Møller, H J, Lange, Aksel, Birkebaek, N H, Holland-Fischer, P, Solvig, J, Hørlyck, A, Kristensen, Kurt, Rittig, S, Handberg, A, Vilstrup, H, Grønbaek, H |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Zdroj: | Kazankov, K, Møller, H J, Lange, A, Birkebaek, N H, Holland-Fischer, P, Solvig, J, Hørlyck, A, Kristensen, K, Rittig, S, Handberg, A, Vilstrup, H & Grønbaek, H 2015, ' The macrophage activation marker sCD163 is associated with changes in NAFLD and metabolic profile during lifestyle intervention in obese children ', Pediatric Obesity, vol. 10, no. 3, pp. 226-233 . https://doi.org/10.1111/ijpo.252 Kazankov, K, Møller, H J, Lange, A, Birkebaek, N H, Holland-Fischer, P, Solvig, J, Hørlyck, A, Kristensen, K, Rittig, S, Handberg, A, Vilstrup, H & Grønbaek, H 2015, ' The macrophage activation marker sCD163 is associated with changes in NAFLD and metabolic profile during lifestyle intervention in obese children ', Pediatric obesity, vol. 10, no. 3, pp. 226-233 . https://doi.org/10.1111/ijpo.252 |
| DOI: | 10.1111/ijpo.252 |
| Popis: | BACKGROUND: Obesity is associated with metabolic derangement and non-alcoholic fatty liver disease (NAFLD). Macrophages are involved in liver inflammation and fibrosis, and soluble (s)CD163 is a macrophage activation marker.OBJECTIVES: To associate sCD163 with parameters of paediatric obesity and NAFLD, as well as changes in these parameters during lifestyle intervention.METHODS: We studied 117 obese children during a 10-week lifestyle intervention; 71 completed the 12-month follow-up. We recorded clinical and biochemical data, and performed liver ultrasonography.RESULTS: Baseline sCD163 was higher in children with elevated alanine transaminase (ALT) (2.3 ± 0.7 vs. 2.0 ± 0.6 mg L(-1) , P = 0.03), steatosis (2.3 ± 0.7 vs. 2.0 ± 0.6 mg L(-1) , P = 0.01) and high paediatric NAFLD fibrosis index (2.3 ± 0.7 vs. 1.9 ± 0.6 mg L(-1) , P = 0.03). Baseline sCD163 was independently associated with ALT, cholesterol and high-sensitivity C-reactive protein (hs-CRP). The change in sCD163 during lifestyle intervention was associated with changes in ALT, homeostatic model assessment of insulin resistance (HOMA-IR), hs-CRP and cholesterol, and inversely associated with the change in high-density lipoprotein cholesterol.CONCLUSION: sCD163 was associated with markers of liver injury and metabolic parameters in obese children, and changes in these parameters during lifestyle intervention. This may suggest that activated macrophages play a role in NAFLD and sCD163 may serve as a marker of liver disease severity and treatment effect. |
| Databáze: | OpenAIRE |
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