Photosensitization of isolated mitochondria by hematoporphyrin derivative (Photofrin): effects on bioenergetics

Autor:	Salet, C., Moreno, G., anna atlante, Passarella, S.
Jazyk:	angličtina
Rok vydání:	1991
Zdroj:	Photochemistry and photobiology 53 (1991): 391–393. info:cnr-pdr/source/autori:SALET C, MORENO G, ATLANTE A, PASSARELLA S/titolo:Photosensitization of isolated mitochondria by hematoporphyrin derivative (Photofrin): effects on bioenergetics./doi:/rivista:Photochemistry and photobiology/anno:1991/pagina_da:391/pagina_a:393/intervallo_pagine:391–393/volume:53 Scopus-Elsevier
Popis:	Isolated rat liver mitochondria were incubated in the presence of 6 micrograms/ml of Photofrin and irradiated at the wavelength of 365 nm. After 45 s irradiation (30 W/m2), coupling defined as stimulation of respiration by externally added adenosine 5'-diphosphate (ADP) is totally lost. In contrast, membrane potential created by addition of succinate or adenosine 5'-triphosphate (ATP) is only slightly affected. Similarly, the ADP/O ratio is not modified after 20 s irradiation. These data suggest that modification of the mitochondrial membrane potential is not a primary event after irradiation.
Databáze:	OpenAIRE
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