| Autor: |
Hess, O M, Koch, R, Bamert, C, Krayenbuehl, H P |
| Přispěvatelé: |
University of Zurich, Hess, O M |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Popis: |
In eight anaesthetized closed-chest dogs, acute myocardial ischaemia was produced for 30 to 90 s by inflating a small balloon-catheter, which had been advanced transaortically into the periphery of the left anterior descending coronary artery. Left ventricular high-fidelity pressure measurements and simultaneous angiocardiography were carried out at control and during ischaemia. Left ventricular systolic function was assessed by the left ventricular ejection fraction (EF) as well as by regional shortening in a basal (SH M1), middle (SH M2 and apical (SH M3) segment. Diastolic function was evaluated by the stress-strain relationship using a viscoelastic model. Regional wall stiffness (Kn) was determined in the same three segments (basal, middle and apical), which were used for the evaluation of regional systolic function. For the interindividual comparison of the diastolic stiffness parameters normalization of the strain data was performed by calculating a reference wall circumference (I0) at a common wall stress of 1000 dynes/cm2. During localized myocardial ischaemia left ventricular end-diastolic pressure remained essentially unchanged (7.2 v. 8.3 mm Hg: NS). Left ventricular EF (47 v. 31% P < 0.001), SH M2 (27 v. 14 % P < 0.005) and SH M3 (22 v. 2% P < 0.02) decreased during ischaemia. Kn in the middle (10.0 v. 14.2; P < 0.02) and the apical (9.8 v. 12.7, P < 0.005) segment increased during ischaemia whereas Kn in the non-ischaemic basal segment remained unchanged (9.6 v. 11.8; NS). During ischaemia I0 increased in the middle segment (15.7 v. 17.3 cm; P < 0.005). Our data indicate that during acute ischaemia regional myocardial wall stiffness is increased in the ischaemic segment, but is normal in the non-ischaemic segment. Reference midwall circumference at a common wall stress of 1000 dynes/cm2 is enhanced during acute ischaemia (creep) and corresponds with the increased sarcomere length reported in ischaemic myocardium. Thus, it is suggested that the changes in regional myocardial wall stiffness are related to changes in reference midwall circumference with creep |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
