Dermatokinetics of didecyldimethylammonium chloride and the influence of some commercial biocidal formulations on its dermal absorption in vitro
| Autor: | Buist, H.E., Heer, C. de, Burgsteden, J.A. van, Sandt, J.J.M. van de |
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| Přispěvatelé: | TNO Kwaliteit van Leven |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Biomedical Research Biocide Aldehyde Vehicle effects Drug exposure Chemistry Pharmaceutical Skin Absorption Dermatokinetics Dermal absorption Stratum corneum Administration Cutaneous Permeability Repeated exposure Drug distribution Drug formulation Aqueous solution Humans Tissue Distribution Human tissue Single exposure Drug absorption Cells Cultured Risk assessment Priority journal integumentary system Correlation analysis In vitro study Skin barrier Toxicokinetics Quaternary ammonium chlorides Quaternary Ammonium Compounds Chemistry Kinetics Human cell Biocides Concentration (parameters) Drug penetration Didecyldimethylammonium chloride Skin permeability Female Epidermis Human Disinfectants |
| Zdroj: | Regulatory Toxicology and Pharmacology, 1, 48, 87-92 |
| Popis: | The in vitro dermal absorption kinetics of didecyldimethylammonium chloride (DDAC) was studied after single and multiple exposure. In addition, the influence of biocidal formulations on the absorption of DDAC was investigated. Following dermal exposure to DDAC in aqueous solution, less than 0.5% of the applied dose reached the receptor fluid after 48 h. The apparent permeability coefficient (Kp) was 5 ± 1 cm/h × 10-6 for concentrations 11 mg/mL). However, the amount of DDAC reaching the receptor fluid remained low ( |
| Databáze: | OpenAIRE |
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