Effect of potash on renal profile of albino wistar rats
| Autor: | Ebadan, Mi, Obiazi, Hak, BASIL OBODO, Aiyeki, Ge, Ikede, Re |
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| Zdroj: | BASE-Bielefeld Academic Search Engine International Journal of Herbs and Pharmacological Research; Vol 3, No 4 (2014); 75-79 |
| ISSN: | 2384-6836 2315-537X |
| Popis: | This study is intended to investigate the effect of Potash on renal function. Twenty four (24) Albino wistar rats with mean weight of 126.3±23.9g were used. They were subdivided into four groups -A, B, C and D (n=6 each); with A serving as control while B, C and D served as test groups. Group A received normal feed and water while B, C and D received 3.0g/kg, 6.0g/kg and 9.0g/kg of potash per body weight for 21 days respectively. At the end of the experiment, the animals were sacrificed under light anesthesia to obtain blood samples for the estimation of renal function parameters. Sodium, Potassium, Chloride, Urea, Uric acid and Creatinine was analyzedusing standard analytical chemical methods. The results showed a significant (P0.05) from that of the control. Our findings therefore, suggest that potash may have dosage dependent nephrotoxic and weight reduction potentials and by implication, may induce growth retardation. This indicates therefore, that potash is toxic to the kidney and there is need for further studies. |
| Databáze: | OpenAIRE |
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