Warm Antibody Autoimmune Haemolytic Anaemia Associated with Ovarian Teratoma
| Autor: | Raimundo, P, Coelho, S, Cabeleira, A, Dias, L, Gonçalves, M |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Ovarian Neoplasms/diagnosis
Ovariectomy Ovarian Neoplasms/surgery Diagnosis Differential Coombs Test Teratoma/surgery HSJ MED HSJ CIR Teratoma/immunology Splenectomy Ovarian Neoplasms/immunology HSJ ANPAT Laparoscopy Anemia Hemolytic Autoimmune/immunology Tomography X-Ray Computed Teratoma/diagnosis |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação instacron:RCAAP |
| Popis: | The ovarian cystic teratoma is a rare cause of autoimmune haemolytic anaemia by warm antibodies, resistant to corticotherapy, with few case reports published in the medical literature. We present a case of a 45-year-old woman admitted to hospital due to general weakness. Laboratory studies revealed macrocytic anaemia, biochemical parameters of haemolysis and peripheral spherocytosis. The direct Coombs test was positive. Viral serologies, anti-nuclear antibodies, anti-double-stranded DNA antibodies and β2-microglobulin were negative. CT scan of the thorax, abdomen and pelvis showed a heterogeneous right anexial lesion. The patient was treated with corticotherapy without improvement of anaemia. Regression of extra-vascular haemolysis and normalisation of haemoglobin was obtained only after laparoscopic splenectomy and right ooforectomy, and the histopathology of the right anexial mass revealed a cystic teratoma. Previously published cases controlled the haemolysis by surgically removing the lesion associated with splenectomy. |
| Databáze: | OpenAIRE |
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