Estimating intra-axonal axial diffusivity with diffusion MRI in the presence of fibre orientation dispersion
| Autor: | Howard, A.F.D., Khrapitchev, A.A., Mollink, J., Mars, R.B., Sibson, N.R., Sallet, J., Jbabdi, S., Miller, K.L. |
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| Rok vydání: | 2020 |
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| Zdroj: | Proceedings of the 28th Annual Meeting of the ISMRM, 1-9. Concord, CA : International Society for Magnetic Resonance in Medicine (ISMRM) STARTPAGE=1;ENDPAGE=9;TITLE=Proceedings of the 28th Annual Meeting of the ISMRM Proceedings of the 28th Annual Meeting of the ISMRM, pp. 1-9 |
| Popis: | Item does not contain fulltext Intra-axonal axial diffusivity could be interesting biomarker of disease, yet it is often assumed constant across the white matter. Furthermore, when intra-axonal diffusivity is estimated, few models account for fibre orientation dispersion which (when not explicitly modelled) will greatly affect the estimates of axial diffusion. Here we combine the stick model of intra-axonal diffusion with a simple model of fibre dispersion to simultaneously estimate intra-axonal axial diffusivity and fibre dispersion on a voxel-wise basis in high b-value data. Our results demonstrate considerable variability in the intra-axonal axial diffusivity across the white matter. 28th Annual Meeting of the International Society for Magnetic Resonance in Medicine (Paris, France, 8-13 August) |
| Databáze: | OpenAIRE |
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