| Autor: |
Vucic, E., Dickson, S.D., Calcagno, C., Rudd, J.H.F., Moshier, E., Hayashi, K., Mounessa, J.S., Roytman, M., Moon, M.J., Lin, J., Tsimikas, S., Fisher, E.A., Nicolay, K., Fuster, V., Fayad, Z.A. |
| Jazyk: |
angličtina |
| Předmět: |
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| Zdroj: |
JACC: Cardiovascular Imaging, 4(10), 1100-1109. Elsevier |
| ISSN: |
1936-878X |
| DOI: |
10.1016/j.jcmg.2011.04.020 |
| Popis: |
Objectives We sought to determine the antiatherosclerotic properties of pioglitazone using multimethod noninvasive imaging techniques. Background Inflammation is an essential component of vulnerable or high-risk atheromas. Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, possesses potent anti-inflammatory properties. We aimed to quantify noninvasively the anti-inflammatory effects of pioglitazone on atheroma using 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI). Methods Atherosclerotic plaques were induced in the aorta of 15 New Zealand white rabbits by a combination of a hyperlipidemic diet and 2 balloon endothelial denudations. Nine rabbits continued the same diet, whereas 6 rabbits received pioglitazone (10 mg/kg orally) in addition to the diet. Twelve animals underwent 18F-FDG-PET/CT, and 15 animals underwent DCE-MRI at baseline, 1 month, and 3 months after treatment initiation. Concomitantly, serum metabolic parameters were monitored. After imaging was completed, aortic histologic analysis and correlation analysis were performed. Results The 18F-FDG-PET/CT imaging detected an increase in average standardized uptake value in the control group (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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