| Autor: |
AŞKIN, CELİL İLKER, Sarioglu, Yusuf, ÖZGER İLHAN, SEVİL, KİBAR, AYŞE KÜBRA, Okcay, Yagmur, KOÇ, DERYA SEBİLE, ÖZTÜRK FİNCAN, GÖKÇE SEVİM, Vural, Ismail Mert |
| Přispěvatelé: |
İstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Sarioglu, Yusuf, AGR-0716-2022 |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Popis: |
Objectives: Endocannabinoids and nicotine regulate the neurotransmitter release in different central and peripheral synapses. Various studies in the literature demonstrate the interaction between endocannabinoid and nicotinic systems, especially in the central nervous system. The interaction between nicotinic and endocannabinoid systems was investigated in this study. We aimed to show the effects of cannabinoid and vanilloid receptor antagonists on nicotine-induced relaxation response increases in rabbit corpus cavernosum. Materials and methods: From a total of seven male albino rabbits, three or four equal strips were cut from each corpus cavernosum and inserted in isolated organ baths. Tissues were contracted with phenylephrine (3×10-5 M). After contraction reached a plateau, strips were stimulated with EFS, and with the stabilization of EFS relaxation responses, 10-4 M of nicotine was administered to tissues. After that, in order to investigate the effects of AM251 (CB1 antagonist), AM630 (CB2 inverse agonist) or capsazepine (a vanilloid receptor antagonist) were given to different tissues, after the resting period. Results: Nicotine (10-4 M) increased the EFS-induced relaxation responses (14.60%±2.94%, P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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