Antiulcer activity of ethanolic extract of Encholirium spectabile Mart. ex Schult & Schult f. (Bromeliaceae) in rodents

Autor:	Moraes Carvalho, Katharinne I., Fernandes, Helio B., Frota Machado, Flavia D., Oliveira, Irisdalva S., Oliveira, Francisco A., Nunes, Paulo Humberto M., Lima, Julianeli T., Jackson Almeida, Meneses Oliveira, Rita C.
Jazyk:	angličtina
Rok vydání:	2010
Předmět:	Encholirium spectabile Bromeliaceae antioxidant lcsh:Biology (General) antiulcer activity lcsh:QH301-705.5
Zdroj:	Biological Research, Vol 43, Iss 4, Pp 459-465 (2010) Biological Research, Volume: 43, Issue: 4, Pages: 459-465, Published: 2010 ResearcherID
ISSN:	0717-6287 0716-9760
Popis:	This study evaluated the antiulcer activity of an ethanolic extract of Encholirium spectabile (ES-EtOH) by using different standard experimental models of induced acute gastric ulceration. ES-EtOH (100 mg/kg p.o) protected the gastric mucosa against ulceration that was induced by absolute ethanol (53%), ethanol/HCl (75 %), ibuprofen (52 %) and ischemia/reperfusion (43 %). It also restored catalase activity and non-protein sulfhydryl group concentration in the gastric wall of mice that had been treated with ethanol. The pre-treatment of mice with N-nitro-L-arginine (70 mg/kg i.p.) abolished the protective activity of ES-EtOH, which indicates that prostaglandins, antioxidant compounds and nitric oxide synthase activity are involved in the gastroprotective activity of the extract.
Databáze:	OpenAIRE
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