Ring chromosome 4 as the sole cytogenetic anomaly in a chondroblastoma:A case report and review of the literature

Autor: Van Zelderen-Bhola, Shama L., Bovée, Judith V.M.G., Wessels, Hans W., Mollevanger, Paul, Nijhuis, Jeroen V., Van Eendenburg, Jaap D.H., Taminiau, Anthonie H.M., Hogendoorn, Pancras C.W.
Přispěvatelé: Human genetics
Jazyk: angličtina
Rok vydání: 1998
Zdroj: Van Zelderen-Bhola, S L, Bovée, J V M G, Wessels, H W, Mollevanger, P, Nijhuis, J V, Van Eendenburg, J D H, Taminiau, A H M & Hogendoorn, P C W 1998, ' Ring chromosome 4 as the sole cytogenetic anomaly in a chondroblastoma : A case report and review of the literature ', Cancer Genetics and Cytogenetics, vol. 105, no. 2, pp. 109-112 . https://doi.org/10.1016/S0165-4608(98)00016-8
Cancer Genetics and Cytogenetics, 105(2), 109-112. Elsevier Inc.
ISSN: 0165-4608
DOI: 10.1016/S0165-4608(98)00016-8
Popis: Chromosome analysis of a chondroblastoma of the right distal femur in a 31-year-old male patient revealed o ring chromosome 4 in approximately one- third of the analyzed cells. The remaining cells had a normal karyotype. These findings were subsequently confirmed by fluorescence in situ hybridization (FISH) with a chromosome-4-specific library. FISH with cosmids pC847.351 (4p16.3) and cT171 (4q35) revealed that fewer than 300 kilobase pairs (kbp) are deleted. To our knowledge, ring chromosome 4 has never been reported in this type of neoplasm. There are, however, several reports of chondroblastoma with other chromosome abnormalities, but the relation of these anomalies to this tumor specifically is unclear. In this report, we also provide a review of the literature concerning cytogenetic studies in chondroblastoma. The possible significance of ring chromosome 4 in this type of tumor is discussed.
Databáze: OpenAIRE
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