Urine metabolites are associated with glomerular lesions in type 2 diabetes
| Autor: | Saulnier, Pierre-Jean, Darshi, Manjula, Wheelock, Kevin M, Looker, Helen C, Fufaa, Gudeta D, Knowler, William C, Weil, E Jennifer, Tanamas, Stephanie K, Lemley, Kevin V, Saito, Rintaro, Natarajan, Loki, Nelson, Robert G, Sharma, Kumar |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Kidney Disease Clinical Sciences Renal and urogenital Kidney Function Tests Analytical Chemistry Indians Clinical Research Diabetes Mellitus Metabolites Humans Diabetic Nephropathies Metabolic and endocrine Kidney structure Prevention Diabetes Middle Aged Type 2 Diabetes Cross-Sectional Studies Metabolome Female Biochemistry and Cell Biology Type 2 North American Biomarkers Glomerular Filtration Rate |
| Zdroj: | Metabolomics : Official journal of the Metabolomic Society, vol 14, iss 6 |
| Popis: | INTRODUCTION:Little is known about the association of urine metabolites with structural lesions in persons with diabetes. OBJECTIVES:We examined the relationship between 12 urine metabolites and kidney structure in American Indians with type 2 diabetes. METHODS:Data were from a 6-year clinical trial that assessed renoprotective efficacy of losartan, and included a kidney biopsy at the end of the treatment period. Metabolites were measured in urine samples collected within a median of 6.5months before the research biopsy. Associations of the creatinine-adjusted urine metabolites with kidney structural variables were examined by Pearson's correlations and multivariable linear regression after adjustment for age, sex, diabetes duration, hemoglobin A1c, mean arterial pressure, glomerular filtration rate (iothalamate), and losartan treatment. RESULTS:Participants (n = 62, mean age 45 ± 10years) had mean ± standard deviation glomerular filtration rate of 137 ± 50ml/min and median (interquartile range) urinealbumin:creatinine ratio of 34 (14-85) mg/g near the time of the biopsy. Urine aconitic and glycolic acids correlated positively with glomerular filtration surface density (partial r = 0.29, P = 0.030 and r = 0.50, P |
| Databáze: | OpenAIRE |
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