| Autor: |
Nicoll, JA, Mrak, RE, Graham, DI, Stewart, J, Wilcock, G, MacGowan, S, Esiri, MM, Murray, LS, Dewar, D, Love, S, Moss, T, Griffin, WS |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Popis: |
Interleukin-1 (IL-1) is markedly overexpressed in Alzheimer's disease. We found the IL-1A 2,2 genotype in 12.9% of 232 neuropathologically confirmed Alzheimer's disease patients and 6.6% of 167 controls from four centers in the United Kingdom and United States (odds ratio, 3.0; controlled for age and for ApoE [apolipoprotein E] genotype). Homozygosity for both allele 2 of IL-1A and allele 2 of IL-1B conferred even greater risk (odds ratio, 10.8). IL-1 genotypes may confer risk for Alzheimer's disease through IL-1 overexpression and IL-1-driven neurodegenerative cascades. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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