Live bacterial delivery systems for development of mucosal vaccines
| Autor: | Thole, J.E.R., Dalen, P.J. van, Havenith, C.E.G., Pouwels, P.H., Seegers, J.F.M.L., Tielen, F.D., Zee, M.D. van der, Zegers, N.D., Shaw, M. |
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| Přispěvatelé: | Centraal Instituut voor Voedingsonderzoek TNO |
| Rok vydání: | 2000 |
| Předmět: |
Commensal bacteria
Gene expression system Drug carrier Lactic acid bacterium Staphylococcus Recombinant vaccine Drug delivery system Genetic Vectors Review Vaccines Attenuated Drug research Mycobacterium Mucosa Bacterium Drug Delivery Systems Mucosal immunity Salmonella Animals Humans Animalia Attenuated bacteria Immune response Staphylococcus carnosus Lactobacillus mucosae Antigen expression Vibrio cholerae Immunity Mucosal Bacteria (microorganisms) Nutrition Vaccines Synthetic Bacteria Streptococcus Lactococcus lactis Mucosal vaccines Lactobacillus Oral vaccines Streptococcus gordonii BCG Vaccine Vaccine |
| Zdroj: | Current Opinion in Molecular Therapeutics, 1, 2, 94-99 |
| Popis: | By expression of foreign antigens in attenuated strains derived from bacterial pathogens and in non-pathogenic commensal bacteria, recombinant vaccines are being developed that aim to stimulate mucosal immunity. Recent advances in the pathogenesis and molecular biology of these bacteria have allowed rational development of new and improved bacterial carriers and more effective gene expression systems. These advances have improved the performance and versatility of these delivery systems to induce mucosal immunity to recombinant antigens in animal models. Application of these (improved) technologies for development of human vaccines is still limited and awaits further exploration Chemicals/CAS: BCG Vaccine; Vaccines, Attenuated; Vaccines, Synthetic |
| Databáze: | OpenAIRE |
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