| Autor: |
Canepa, M, Fumagalli, C, Tini, G, Vincent-Tompkins, J, Day, SM, Ashley, EA, Mazzarotto, F, Ware, J, Michels, M, Jacoby, M, Ho, CY, Olivotto, I, The SHaRe Investigators |
| Přispěvatelé: |
Wellcome Trust, British Heart Foundation |
| Rok vydání: |
2020 |
| Předmět: |
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| Popis: |
BACKGROUND Over the last 50 years, the epidemiology of hypertrophic cardiomyopathy (HCM) has changed due to increased awareness and availability of advanced diagnostic tools. We aim to describe the temporal trends in age, gender and clinical characteristics at HCM diagnosis over >4 decades. METHODS We retrospectively analyzed records from the ongoing multinational SHaRe registry. Overall, 7,286 HCM patients diagnosed at an age ≥18 years between 1961 and 2019 were included in the analysis and divided into three eras of diagnosis (2010). RESULTS Age at diagnosis increased markedly over time (40±14 vs. 47±15 vs. 51±16 years, p30 mmHg: 31.9% vs. 39.3% vs. 39.0%, p=0.001). Consistent with decreasing phenotypic severity, yield of pathogenic/likely-pathogenic variants at genetic testing decreased over time (57.7% vs. 45.6% vs. 38.4%, p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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