Risk factors for neurodegeneration in idiopathic rapid eye movement sleep behavior disorder: A multicenter study

Autor: Postuma RB, Iranzo A, Hogl B, Arnulf I, FERINI STRAMBI , LUIGI, Manni R, Miyamoto T, Oertel W, Dauvilliers Y, Ju YE, Puligheddu M, Sonka K, Pelletier A, Santamaria J, Frauscher B, Leu Semenescu S, Zucconi M, Terzaghi M, Miyamoto M, Unger MM, Carlander B, Fantini ML, Montplaisir J.Y.
Přispěvatelé: McGill University = Université McGill [Montréal, Canada], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Département de neurologie [Montpellier], Hôpital Gui de Chauliac [Montpellier]-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), Hôpital du Sacré-Coeur de Montréal, Postuma, Rb, Iranzo, A, Hogl, B, Arnulf, I, FERINI STRAMBI, Luigi, Manni, R, Miyamoto, T, Oertel, W, Dauvilliers, Y, Ju, Ye, Puligheddu, M, Sonka, K, Pelletier, A, Santamaria, J, Frauscher, B, Leu Semenescu, S, Zucconi, M, Terzaghi, M, Miyamoto, M, Unger, Mm, Carlander, B, Fantini, Ml, Montplaisir, J. Y.
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Annals of Neurology
Annals of Neurology, Wiley, 2015, 77 (5), pp.830-839. ⟨10.1002/ana.24385⟩
ISSN: 0364-5134
1531-8249
DOI: 10.1002/ana.24385⟩
Popis: International audience; OBJECTIVE:To assess whether risk factors for Parkinson disease and dementia with Lewy bodies increase rate of defined neurodegenerative disease in idiopathic rapid eye movement (REM) sleep behavior disorder (RBD).METHODS:Twelve centers administered a detailed questionnaire assessing risk factors for neurodegenerative synucleinopathy to patients with idiopathic RBD. Variables included demographics, lifestyle factors, pesticide exposures, occupation, comorbid conditions, medication use, family history, and autonomic/motor symptoms. After 4 years of follow-up, patients were assessed for dementia or parkinsonism. Disease risk was assessed with Kaplan-Meier analysis, and epidemiologic variables were compared between convertors and those still idiopathic using logistic regression.RESULTS:Of 305 patients, follow-up information was available for 279, of whom 93 (33.3%) developed defined neurodegenerative disease. Disease risk was 25% at 3 years and 41% after 5 years. Patients who converted were older (difference = 4.5 years, p
Databáze: OpenAIRE
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