Antidiabetic properties of the methanolic extract of Bridelia grandis (Euphorbiacae) in ob/ob and db/db mice
| Autor: | Njamen, D., Nkeh-Chungag, B. N., Djiogue, S., Yankep, E., Noudji, E. M., Djapou, J., Kentsop, A. C. G., Jean Claude N Mbanya |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | African Journal of Biotechnology; Vol 10, No 13 (2011); 2520-2523 Scopus-Elsevier |
| ISSN: | 1684-5315 |
| Popis: | Bridelia grandis is used in most parts of tropical Africa for the treatment of diabetes. The anti-diabetic properties of the methanolic stem bark extract of this plant was studied in ob/ob and db/db mice. The plant extract induced hypoglycaemic effects of long duration in the ob/ob mice, while its effects were less pronounced in the db/db mice. Twenty four hours after the cessation of drug administration, both ob/ob and db/db extract treated animals still had significantly lower fasting blood sugar levels when compared to controls, thus confirming its antidiabetic properties.Key words: Bridelia grandis (Euphorbiaceae), antidiabetic properties, ob/ob and db/db mice. |
| Databáze: | OpenAIRE |
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