Adjuvant Treatment of Melanoma
| Autor: | Moreno Nogueira, J A, Valero Arbizu, M, Pérez Temprano, R |
|---|---|
| Přispěvatelé: | [Moreno Nogueira,JA] Department of Oncology, Virgen del Rocio University Hospital. Royal Academy of Medicine, Seville, Spain. [Valero Arbizu,M] Department of Oncology, Infanta Luisa Hospital, Seville, Spain. [Pérez Temprano,R] Department of Medicine, Virgen Macarena University Hospital, Seville, Spain. |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Recurrencia local de neoplasia
Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Disease Attributes::Recurrence [Medical Subject Headings] Article Subject Diseases::Neoplasms::Neoplasms by Site::Skin Neoplasms [Medical Subject Headings] Proliferación de la célula Ganglios linfáticos Diseases::Neoplasms::Neoplastic Processes::Neoplasm Recurrence Local [Medical Subject Headings] Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms Germ Cell and Embryonal::Neuroectodermal Tumors::Neuroendocrine Tumors::Melanoma [Medical Subject Headings] Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] Analytical Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures Operative::Lymph Node Excision [Medical Subject Headings] Interferón-alfa Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis [Medical Subject Headings] Chemicals and Drugs::Amino Acids Peptides and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Interferons::Interferon Type I::Interferon-alpha [Medical Subject Headings] Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Growth Processes::Cell Proliferation [Medical Subject Headings] Melanoma Anatomy::Tissues::Lymphoid Tissue::Lymph Nodes [Medical Subject Headings] Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Phosphatidylinositol 3-Kinases::Phosphatidylinositol 3-Kinase [Medical Subject Headings] neoplasms Fosfatidilinositol 3-quinasas |
| Zdroj: | ISRN Dermatology. |
| DOI: | 10.1155/2013/545631 |
| Popis: | Journal Article; Melanomas represent 4% of all malignant tumors of the skin, yet account for 80% of deaths from skin cancer.While in the early stages patients can be successfully treated with surgical resection, metastatic melanoma prognosis is dismal. Several oncogenes have been identified in melanoma as BRAF, NRAS, c-Kit, and GNA11 GNAQ, each capable of activating MAPK pathway that increases cell proliferation and promotes angiogenesis, although NRAS and c-Kit also activate PI3 kinase pathway, including being more commonly BRAF activated oncogene. The treatment of choice for localised primary cutaneous melanoma is surgery plus lymphadenectomy if regional lymph nodes are involved. The justification for treatment in addition to surgery is based on the poor prognosis for high risk melanomas with a relapse index of 50-80%. Patients included in the high risk group should be assessed for adjuvant treatment with high doses of Interferon- α 2b, as it is the only treatment shown to significantly improve disease free and possibly global survival. In the future we will have to analyze all these therapeutic possibilities on specific targets, probably associated with chemotherapy and/or interferon in the adjuvant treatment, if we want to change the natural history of melanomas. Yes |
| Databáze: | OpenAIRE |
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