PANDAS: diagnostic and therapeutic challenges, case report and literature review
| Autor: | Hodak, Kristian |
|---|---|
| Přispěvatelé: | Jelušić, Marija, Vuković, Jurica, Senečić-Čala, Irena |
| Jazyk: | chorvatština |
| Rok vydání: | 2021 |
| Předmět: |
obsessive-compulsive disorder
pedijatrijski autoimunosni neuropsihijatrijski poremećaj udružen sa streptokoknom infekcijom streptokok skupine A streptolizin opsesivno-kompulzivni poremećaj tikovi antistreptolysin group A streptococcal infection tics pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections |
| Popis: | Pedijatrijski autoimunosni neuropsihijatrijski poremećaji udruženi sa streptokoknom infekcijom (PANDAS, engl. pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections) predstavljaju kontroverzni klinički entitet u medicinskoj praksi zbog nedovoljno poznate etiopatogeneze, nepostojanja specifičnog biljega za potvrdu dijagnoze te teško dokazive uzročno-posljedične veze između infekcije ß-hemolitičkim streptokokom skupine A (BHSA) i pojave simptoma ovog poremećaja. Očituje se naglo nastalim simptomima i znakovima opsesivno-kompulzivnog poremećaja (OKP) i/ili tikovima, a koji su povezani s nedavnom infekcijom BHSA-om. U radu smo prikazali bolesnicu s PANDAS-om uz kratak pregled literature vezano uz etiopatogenezu, dijagnostiku i liječenje pri čemu smo željeli naglasiti složenost ovog poremećaja zbog velikih različitosti u kliničkoj slici, nemogućnosti postavljanja sigurne dijagnoze i prijepora u odabiru učinkovitih metoda liječenja. Iz navedenoga je razvidno da mnoga pitanja u svezi s PANDAS-om ostaju otvorena te da su potrebna daljnja istraživanja i multidisciplinarni pristup kako bi se bolje upoznao ovaj kompleksni klinički entitet. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) is a controversial clinical entity in medical practice due to insufficiently known etiopathogenesis, lack of specific markers for confirmation of the diagnosis, and difficult-to-prove causal relationship between a group A ß-haemolytic streptococcal (GABHS) infection and the onset of symptoms. It presents with a sudden onset of symptoms and signs of obsessive-compulsive disorder (OCD) and/or tics, which are associated with a recent GABHS infection. We presented a patient with PANDAS as well as a brief overview of the literature concerning the etiopathogenesis, diagnostics and treatment while emphasizing the complexity of this disorder due to the large variations in clinical presentation, the inability to make a reliable diagnosis, and the controversies in choosing effective treatment methods. It is evident that many of the issues surrounding PANDAS remain open and that further research and a multidisciplinary approach are needed to better understand this complex clinical entity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|