Mass Oral Azithromycin for Childhood Mortality: Timing of Death After Distribution in the MORDOR Trial

Autor:	Porco, Travis C, Hart, John, Arzika, Ahmed M, Weaver, Jerusha, Kalua, Khumbo, Mrango, Zakayo, Cotter, Sun Y, Stoller, Nicole E, O'Brien, Kieran S, Fry, Dionna M, Vanderschelden, Benjamin, Oldenburg, Catherine E, West, Sheila K, Bailey, Robin L, Keenan, Jeremy D, Lietman, Thomas M, Macrolides Oraux pour Réduire les Décès avec un Oeil sur la Rési
Rok vydání:	2019
Předmět:	Trachoma Male azithromycin childhood mortality sub-Saharan Africa Pediatric Time Factors Clinical Trials and Supportive Activities Infant Biological Sciences Newborn Medical and Health Sciences Microbiology Anti-Bacterial Agents Good Health and Well Being Clinical Research Child Mortality Infant Mortality Humans Mass Drug Administration Female Macrolides Oraux pour Réduire les Décès avec un Oeil sur la Résistance (MORDOR) Study Group Child Preschool
Zdroj:	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol 68, iss 12
ISSN:	1058-4838
Popis:	In a large community-randomized trial, biannual azithromycin distributions significantly reduced postneonatal childhood mortality in sub-Saharan African sites. Here, we present a prespecified secondary analysis showing that much of the protective effect was in the first 3 months postdistribution. Distributing more frequently than biannually could be considered if logistically feasible. Clinical Trials Registration. NCT02047981.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ba65fa2c86a30e8220e2c08d331744fa https://escholarship.org/uc/item/5bs039c9 Zobrazit plný text záznamu