Case study of a patient with non-metastatic prostate cancer and resistant hypertension as a side effect of apalutamide

Autor: Dobrić, Maja
Přispěvatelé: Mucalo, Iva
Jazyk: chorvatština
Rok vydání: 2022
Předmět:
Popis: U ovome diplomskom radu prikazan je slučaj pacijenta s nemetastatskim karcinomom prostate rezistentnim na kastraciju. Pacijent je pristupio Farmakoterapijskom savjetovalištu s primarnim terapijskim problemom bolova u zglobovima na koje je sumnjao da su se javili kao nuspojava estramustina, lijeka koji mu je bio propisan u terapiji karcinoma. Prilikom konzultacija provedenih u Savjetovalištu, u dogovoru s liječnikom obiteljske medicine i specijalistom onkologije, lijek je zamijenjen apalutamidom, lijek indiciran za nemetastatski karcinom prostate rezistentnan na kastraciju. Apalutamid pripada skupini antiandrogena (hormonska terapija) te je na Hrvatsko tržište stavljen 2020. godine. Na terapiji apalutamidom vrijednosti PSA i testosterona su mu bile dobro regulirane, no javila mu se nuspojava hipertenzije refraktorna na sve terapjiske kombinacije antihipertenziva. Nakon što su isprobane različite kombinacije lijekova za liječenje hipertenzije kroz devet konzultacija u periodu od dvije godine te mu krvni tlak usprkos svim kombinacijama nije bio uspješno reguliran, donosi se zaključak kako je riječ o rezistentnoj hipertenziji. Stoga, kada se na tržištu pojavio darolutamid, također lijek s antiandrogenim učinkom, pacijentu se apalutamid zamjenio s darolutamidom zbog manje vjerojatnosti razvoja hipertenzije kao nuspojave. Cilj ovog diplomskog rada bio je detaljno prikazati slučaj jednoga pacijenta s nemetastatskim karcinomom prostate kod kojeg se primjenom novog lijeka za liječenje karcinoma prostate-apalutamida razvila nuspojava rezistentne hipertenzije. S obzirom da je cilj bio detaljan prikaz provedenih konzultacija koje su dovele do regulacije krvnog tlaka istraživanje se provelo metodom prikaza slučaja (eng. Case study). This thesis presents the case of a patient with castration-resistant non-metastatic prostate cancer. The patient approached the Pharmacotherapy Consultation (Farmakoterapijsko savjetovalište) with a primary therapeutic problem of joint pain, which he suspected was a side effect of estramustine, a drug prescribed for cancer therapy. During consultations carried out in the center, in agreement with a family medicine doctor and an oncology specialist, the drug was replaced with apalutamide, a drug indicated for castration-resistant non-metastatic prostate cancer. Apalutamide belongs to the group of antiandrogens (hormonal therapy) and was put on the Croatian market in 2020. During apalutamide therapy, his PSA and testosterone values were well regulated, but he developed a side effect of hypertension refractory to all therapeutic combinations of antihypertensive drugs. After different combinations of drugs for the treatment of hypertension were tried through nine consultations over a period of two years, and his blood pressure was not successfully regulated despite all the combinations, it was concluded that it was resistant hypertension. Therefore, when darolutamide, also a drug with an antiandrogenic effect, appeared on the market, apalutamide was replaced by darolutamide in the patient due to the lower likelihood of developing hypertension as a side effect. The aim of this thesis was to present in detail the case of one patient with non-metastatic prostate cancer in whom the side effect of resistant hypertension developed after the use of a new drug for the treatment of prostate cancer - apalutamide. Given that the goal was a detailed presentation of the consultations that led to the regulation of blood pressure, the research was conducted using the case study method.
Databáze: OpenAIRE
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