Effects of Galanin N-Terminal fragment (1-15) in the anhedonic behavioural tests in rats
| Autor: | Garcia-Cantero, Noelia, Flores-Burgess, Antonio, Gago, Belén, García-Durán, Laura, Alén, Francisco, Orio, Laura, Narváez, José Ángel, Fuxe, Kjell, Santin-Nuñez, Luis Javier, Díaz-Cabiale, Zaida, Millón, Carmelo |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | RIUMA. Repositorio Institucional de la Universidad de Málaga instname RIUMA: Repositorio Institucional de la Universidad de Málaga Universidad de Málaga |
| Popis: | The Galanin N-terminal fragment (1-15)[GAL(1-15)] induces depressant- and anxiogenic-like actions in behavioural tests in rats. Since anhedonia is a core feature of depression, we have analyzed GAL(1-15) actions in anhedonic-like behaviour tests: saccharin Self-administration, Sucrose Preference test (SPT), Novelty suppressed feeding (NSF) and Female urine sniffing test (FUST). Three sets of experiments were conducted in the saccharin Self-administration. First, a dose-response curve of GAL(1-15) 1nmol, 3nmol or vehicle was performed. We have also compared the effects in the number of saccharine reinforcements of GAL 3nmol and GAL(1-15) 3nmol. In the last experiments, rats received GAL(1-15) 3nmol and the GALR2 antagonist M871 3nmol. In SPT, NSF and FUST we have analyzed the effects of GAL(1-15) 3nmol in the sucrose intake and preference, the latency of the first feeding episode and the female urine sniffing duration respectively. GAL(1-15)3nmol significantly decreased the number of reinforcement of saccharin self-administer (p |
| Databáze: | OpenAIRE |
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