Liver spheroids: a robust human in vitro system for testing the therapeutic options of cyclooxygenase 2 in NAFLD/NASH
| Autor: | Huete, Javier, Fuertes-Agudo, Marina, Brea, Rocío, Luque-Tévar, María, Cucarella, Carme, Martín-Sanz, Paloma, Casado, Marta |
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| Přispěvatelé: | Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, European Commission |
| Rok vydání: | 2021 |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | Trabajo presentado en las XV Jornadas CIBER Enfermedades Hepáticas y Digestivas: Jornades científiques del CIBERehd, celebradas en modalidad virtual y de forma presencial en Barcelona (España) del 08 al 09 de noviembre de 2021. Cyclooxygenase (COX) is a key enzyme in the biosynthesis of prostanoids. Prostaglandins are involved in multiple homeostatic processes, as well as playing an important role in the onset of inflammation. COX-2 is an isoform that is expressed and induced by different stimuli in various tissues and cell types; however, in liver, COX-2 expression is restricted to those situations where proliferation and dedifferentiation occur (1). Our previous results have shown that COX-2 expression in hepatocytes protects against hyperglycemia-induced liver damage, peripheral insulin resistance and adiposity in mice fed a high-fat diet (2), and also protects against experimental non-alcoholic steatohepatitis and fibrosis (3). This work was supported by SAF2016-75004-R and PID2019-108977RB-I00 (MINECO, Spain) and CIBERehd (ISCIII, Spain). M F-A. and M L-T are recipient of FPI fellowship from MINECO (BES-2017-081928 and PRE2020-094885, respectively). We thank FEDER for financial support. |
| Databáze: | OpenAIRE |
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