| Autor: |
Meric Koksal, Bilge, S. S., Bozkurt, A., Sahin, Z. S., Isik, S., Erol, D. D. |
| Přispěvatelé: |
Ondokuz Mayıs Üniversitesi, Koksal, M., Bilge, S.S., Bozkurt, A., Sahin, Z.S., Isik, S., Erol, D.D., Yeditepe Üniversitesi |
| Jazyk: |
angličtina |
| Rok vydání: |
2008 |
| Předmět: |
|
| Zdroj: |
Scopus-Elsevier |
| Popis: |
PubMed: 19025061 Several 5-(3,4-dichlorophenyl)-2-(aroylmethyl)thio-1,3,4-oxadiazoles were synthesized and characterized by elemental analyses, IR and nuclear magnetic resonance spectra. All compounds were evaluated for anti-inflammatory activity by determining their ability to provide protection against carregeenan-induced edema in rat paw. In addition, ulcerogenic activity was determined. The anti-inflammatory data scoring showed that compounds 5e, 5f and 5g, at the dose of 100 mg/kg, exhibited anti-inflammatory activity, which for compound 5f was comparable to that of the reference drug indometacin (CAS 53-86-1). © ECV Editio Cantor Verlag. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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