The nature of the bond between peptide and carrier molecule determines immunogenicity of the construct

Autor:	Beekman, N.L.C.M., Schaaper, W.M.M., Langeveld, J.P.M., Boshuizen, R.S., Meloen, R.H.
Jazyk:	angličtina
Rok vydání:	2001
Předmět:	Lipo peptide Palmitic acid ID-Lelystad Instituut voor Dierhouderij en Diergezondheid ID Lelystad Institute for Animal Science and Health lipids (amino acids peptides and proteins) Carrier molecule Immunogenicity Labile bond Vaccine Thioester
Zdroj:	Journal of peptide research, 58(3), 237-245 Journal of peptide research 58 (2001) 3
ISSN:	1397-002X
Popis:	The influence of the nature of the bond between a peptide and a (lipidic) carrier molecule on the immunogenicity of that construct was investigated. As types of bonds a thioester-, a disulfide-, an amide- and a thioether bond were investigated. As carrier molecules a peptide, an N-palmitoylated peptide or a C16-hydrocarbon chain were used. The biostability of the bond between peptide and carrier molecule is thioether > amide > disulfide thioester. However, the immunogenic potency of the constructs used was found to be thioester > disulfide > amide > thioether. In conclusion, a construct with a bond between peptide and (lipidic) carrier molecule that is more susceptible to biological degradation is more immunogenic when used in a peptide-based vaccine than a bond that is less susceptible to biological degradation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b752c0b7e7026d186a4aaa1d12c2b3f5 https://research.wur.nl/en/publications/the-nature-of-the-bond-between-peptide-and-carrier-molecule-deter Zobrazit plný text záznamu Plný text