Human Vγ9Vδ2 T Lymphocytes in the Immune Response to P. falciparum Infection
| Autor: | Howard, Jennifer, Zaidi, Irfan, Loizon, Séverine, Mercereau-Puijalon, Odile, Déchanet-Merville, Julie, Mamani-Matsuda, Maria |
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| Přispěvatelé: | National Institute of Allergy and Infectious Diseases [Bethesda] (NIAID-NIH), National Institutes of Health [Bethesda] (NIH), Immunology from Concept and Experiments to Translation (ImmunoConcept), Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB), Département Parasites et Insectes vecteurs - Department of Parasites and Insect Vectors, Institut Pasteur [Paris], This work was supported in part by grants from the Centre National de la Recherche Scientifique, the French Research Agency [ANR-12-Blanc-GDSTRESS] and the Fondation pour la Recherche Médicale (FRM, équipe labellisée). JH and IZ are supported by the Intramural Research Program of the National Institute of Allergy and Infectious Disease, NIH., ANR-12-BSV3-0024,GDSTRESS,Détection du stress cellulaire par les lymphocytes T gamma/delta humains(2012), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
MESH: Humans MESH: Erythrocytes MESH: Malaria Falciparum malaria gamma-delta T cells immunity to malaria MESH: T-Lymphocyte Subsets antigen presenting cell (APC) [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity falciparum [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology MESH: Receptors Antigen T-Cell gamma-delta [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases parasitic diseases MESH: Antigen Presentation cytotoxicity MESH: Animals MESH: Immunity Innate lcsh:RC581-607 MESH: Adaptive Immunity MESH: Plasmodium falciparum MESH: Antigens Protozoan |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Frontiers, 2018, 9, pp.2760. ⟨10.3389/fimmu.2018.02760⟩ Frontiers in Immunology, Vol 9 (2018) Frontiers in Immunology, 2018, 9, pp.2760. ⟨10.3389/fimmu.2018.02760⟩ |
| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2018.02760⟩ |
| Popis: | International audience; Malaria is an infectious disease caused by the protozoan parasite Plasmodium sp, the most lethal being Plasmodium falciparum. Clinical malaria is associated with the asexual replication cycle of Plasmodium parasites inside the red blood cells (RBCs) and a dysregulated immune response. Although the mechanisms of immune responses to blood-or liver-stage parasites have been extensively studied, this has not led to satisfactory leads for vaccine design. Among innate immune cells responding to infection are the non-conventional gamma-delta T-cells. The Vγ9Vδ2 T-cell subset, found only in primates, is activated in response to non-peptidic phosphoantigens produced by stressed mammalian cells or by microorganisms such as Mycobacteria, E.coli, and Plasmodium. The potential protective role of Vγ9Vδ2 T-cells against infections and cancer progression is of current research interest. Vγ9Vδ2 T-cells have been shown to play a role in the early control of P. falciparum parasitemia and to influence malaria adaptive immunity via cytokine release and antigen presentation. They are activated and expanded during a primary P. falciparum infection in response to malaria phosphoantigens and their activity is modulated upon subsequent infections. Here, we review the wide range of functions by which Vγ9Vδ2 T-cells could both contribute to and protect from malaria pathology, with a particular focus on their ability to induce both innate and adaptive responses. We discuss how the multifunctional roles of these T-cells could open new perspectives on gamma-delta T-cell-based interventions to prevent or cure malaria. |
| Databáze: | OpenAIRE |
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