Changing to NIPT as a first-tier screening test and future perspectives: opinions of health professionals

Autor: Tamminga, Saskia, van Schendel, Rachel V., Rommers, Wieke, Bilardo, Caterina M., Pajkrt, Eva, Dondorp, Wybo J., van Maarle, Merel, Cornel, Martina C., Henneman, Lidewij
Přispěvatelé: Other departments, APH - Amsterdam Public Health, ARD - Amsterdam Reproduction and Development, Obstetrics and Gynaecology, Human Genetics, Reproductive Origins of Adult Health and Disease (ROAHD)
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Prenatal diagnosis, 35(13), 1316-1323. John Wiley and Sons Ltd
Prenatal Diagnosis, 35(13), 1316-1323. Wiley-Blackwell
ISSN: 0197-3851
Popis: Objective The aim of this study was to investigate health professionals' opinions toward offering noninvasive prenatal testing (NIPT) as first-tier screening test regardless of pregnant women's risk, and toward a potential broader range of disorders. Methods A questionnaire completed by obstetric health professionals (n = 240) after an in-service NIPT training in the West and North of the Netherlands. Results The majority (72%) of respondents favored replacing first-trimester combined test (FCT) by NIPT, although 43% preferred to maintain nuchal translucency measurement. Many respondents believed that replacing FCT by NIPT would only have advantages (57%), would lead to more pregnant women opting for prenatal testing (69%), and would simplify counseling (47%). Differences in attitudes toward counseling between health professionals were observed. When considering NIPT to screen for broader range of disorders, the majority (92%) thought that this should include disorders characterized by neonatal death, whereas 52% of the respondents favored testing for fetomaternal risk factors. Overall, 46% thought screening should be offered as a fixed list of disorders. Conclusion Most health professionals favor NIPT instead of FCT but prefer to maintain nuchal translucency measurement. If NIPT becomes available as a first-tier screening test, attention remains necessary to ensure that pregnant women make well-informed decisions in line with the aim of prenatal screening. (C) 2015 John Wiley & Sons, Ltd.
Databáze: OpenAIRE
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