| Autor: |
Fitzgerald, Felicity C, Lhomme, Edouard, Harris, Kathryn, Kenny, Julia, Doyle, Ronan, Kityo, Cissy, Shaw, Liam P, Abongomera, George, Musiime, Victor, Cook, Adrian, Brown, Julianne R, Brooks, Anthony, Owen-Powell, Ellen, Gibb, Diana M, Prendergast, Andrew J, Sarah Walker, A, Thiebaut, Rodolphe, Klein, Nigel, CHAPAS-3 Trial Team |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| ISSN: |
0022-1899 |
| Popis: |
Objective: Immune activation is associated with morbidity and mortality during human immunodeficiency virus (HIV) infection, despite receipt of antiretroviral therapy (ART). We investigated whether microbial translocation drives immune activation in HIV-infected Ugandan children. Methods: Nineteen markers of immune activation and inflammation were measured over 96 weeks in HIV-infected Ugandan children in the CHAPAS-3 Trial and HIV-uninfected age-matched controls. Microbial translocation was assessed using molecular techniques, including next-generation sequencing. Results: Of 249 children included, 142 were infected with HIV; of these, 120 were ART naive, with a median age of 2.8 years (interquartile range [IQR], 1.7-4.0 years) and a median baseline CD4+ T-cell percentage of 20% (IQR, 14%-24%), and 22 were ART experienced, with a median age of 6.5 years (IQR, 5.9-9.2 years) and a median baseline CD4+ T-cell percentage of 35% (IQR, 31%-39%). The control group comprised 107 children without HIV infection. The median increase in the CD4+ T-cell percentage was 17 percentage points (IQR, 12-22 percentage points) at week 96 among ART-naive children, and the viral load was |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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