| Autor: |
Ge, H, Riss, PJ, Mirabello, V, Calatayud, DG, Flower, SE, Arrowsmith, RL, Fryer, TD, Hong, Y, Sawiak, S, Jacobs, RM, Botchway, SW, Tyrrell, RM, James, TD, Fossey, JS, Dilworth, JR, Aigbirhio, FI, Pascu, SI |
| Rok vydání: |
2017 |
| DOI: |
10.1016/j.chempr.2017.06.013 |
| Popis: |
Hybrid materials based on supramolecularly assembled single-walled carbon nanotubes (SWNTs) are generated for positron emission tomography (PET), magnetic resonance imaging, and fluorescence imaging. The all-in-one imaging probe allows quantitative imaging from subcellular resolution to whole tissue regions. The SWNTs can be exposed to aqueous solutions of non-radioactive and radioactive metal salts in the presence of fullerenes and b-D-glucan. Encapsulating 64Cu ions achieves a minimum of 69% incorporation of radiochemical. The results suggest that this method can be extended to other metal ions of medical relevance, such as zirconium(IV)-89 or rhenium(VII)-188, which are used for medical imaging or radiotherapy, respectively. The in vivo uptake of 64Cu(II)@SWNT@glucan in Wistar rats allows the investigation of organ biodistribution by microPET. Radioactivity rapidly accumulates predominantly in the lungs and myocardium with peak uptakes of 4.8 G 0.9 standardized uptake value. Furthermore, such materials are fully traceable in cells by multiphoton fluorescence lifetime imaging with near-infrared excitation (910 nm). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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