Effects of omeprazole on the number of immunoreactive gastrin- and somatostatin-cells in the rat gastric mucosa

Autor:	Pawlikowski, M., Karbownik, M., Andrzej Lewinski, Pisarek, H., Wajs, E., Szkudlinski, M.
Jazyk:	angličtina
Rok vydání:	1992
Předmět:	6 - Ciencias aplicadas::61 - Medicina [CDU] digestive oral and skin physiology Gastric antral mucosa digestive system hormones hormone substitutes and hormone antagonists digestive system diseases Omeprazole
Zdroj:	DIGITUM. Depósito Digital Institucional de la Universidad de Murcia instname Scopus-Elsevier
Popis:	The effects of omeprazole - an inhibitor of gastric acid secretion - on gastrin (G)- and somatostatin (D)-cell density in the gastric antral mucosa epithelium in rats were examined, following a 5-day treatment. It was found that omeprazole increased the density of G-cells, whereas it decreased the density of D-cells. That effect was probably independent of hypergastrinaemia, since it could not be blocked by a simultaneous treatment with proglumide - a gastrin receptor blocker. It is concluded that the observed phenomenon is a direct result of a lower gastric acidity, as a consequence of omeprazole treatment.
Databáze:	OpenAIRE
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